Author's response to reviews Title:Gross cystic disease fluid protein 15 (GCDFP-15) expression in breast cancer subtypes Authors:
نویسندگان
چکیده
Silvia Darb-Esfahani ([email protected]) Gunter von Minckwitz ([email protected]) Carsten Denkert ([email protected]) Beyhan Ataseven ([email protected]) Bernhard Högel ([email protected]) Keyur Mehta ([email protected]) Gabriele Kaltenecker ([email protected]) Thomas Rüdiger ([email protected]) Berit Pfitzner ([email protected]) Kornelia Kittel ([email protected]) Bettina Fiedler ([email protected]) Klaus Baumann ([email protected]) Roland Moll ([email protected]) Manfred Dietel ([email protected]) Holger Eidtmann ([email protected]) Christoph Thomssen ([email protected]) Sibylle Loibl ([email protected])
منابع مشابه
Gross cystic disease fluid protein in nipple aspirates of breast fluid of Asian and non-Asian women.
Gross cystic disease fluid protein 15 (GCDFP-15) is universally present in the apocrine metaplastic epithelium of cystic breast disease and breast cancer, but it is rarely found in normal breast epithelium. Therefore GCDFP-15 detected in nipple aspirates of breast fluid (NAF) could serve as a biochemical marker of the presence and possibly extent of apocrine metaplasia within the breast. GCDFP-...
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PURPOSE Proteomic analysis of breast nipple aspirate fluid (NAF) holds promise as a noninvasive method to identify markers of breast cancer. The objectives of the study were to: (a) describe the NAF proteome, (b) identify candidate markers of breast cancer in NAF by using proteomic analysis, and (c) validate the markers identified by using a quantitative, high-throughput ELISA analysis. EXPER...
متن کاملGross Cystic Disease Fluid Protein in Nipple Aspirates of Breast Fluid of Asian and Non-Asian Women1
Gross cystic disease fluid protein 1 5 (GCDFP-1 5) is universally present in the apocrine metaplastic epithelium of cystic breast disease and breast cancer, but it is rarely found in normal breast epithelium. Therefore GCDFP-15 detected in nipple aspirates of breast fluid (NAF) could serve as a biochemical marker of the presence and possibly extent of apocrine metaplasia within the breast. GCDF...
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OBJECTIVES Estrogen receptor (ER), gross cystic disease fluid protein 15 (GCDFP-15), and mammaglobin (MGB) are commonly used breast-specific immunomarkers; however, about half of metastatic breast carcinomas are negative for all three. GATA-binding protein 3 (GATA-3) has emerged recently as a sensitive and relatively specific immunomarker for breast and urothelial carcinomas, but the data docum...
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BACKGROUND Among the many challenges in cancer diagnosis is the early distinction between metastatic cancer and a secondary tumor. This difficulty stems from the lack of markers that offer high sensitivity and specificity and can be easily applied in routine laboratory work. An example of this challenge is distinguishing gastric metastases originating from breast cancer from a gastric primary t...
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